Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC008
Sex MALE
Dominant hand LEFT
Test date and time 2022-02-22 08:21
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment tbl Madopar 250mg 3x1/4 tbl Madopar HBS 1 uvece tbl Rivotril 2mg 1/4 uvece

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 34 individuals with a value less than 0.68 were subsequently diagnosed with PD. That is, 80.95% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.68 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 42, 'TN': 30, 'TP': 0, 'FP': 0}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 1, 'TN': 2, 'TP': 41, 'FP': 28}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 33, 'TN': 28, 'TP': 9, 'FP': 2}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 20, 'TN': 12, 'TP': 22, 'FP': 18}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 10.308
timePerCircleCoV 0.12008
timePerCircleSlope -0.0168625
meanError 1.35943
tremorFreq 6.15234
tremorRelPower 39.7053
tremorGyroAmpMean 0.0129807
tremorGyroAmpSlope -0.00510828
tremorGyroAmpCoV 0.473101
tremorCoordAmpMean 0.0361718
tremorCoordAmpSlope -0.000104908
tremorCoordAmpCoV 0.331197
tremorAccAmpMean 0.0696135
tremorAccAmpSlope -0.000908298
tremorAccAmpCoV 0.0752876
tremorPcRelVar 0.617972
tremorPcX 0.320988
tremorPcY -0.947083

Circle Segment 1

Duration 11.12 s, Accuracy Estimate 1.606 (lower is better)

Circle Segment 2

Duration 10.2 s, Accuracy Estimate 1.235 (lower is better)

Circle Segment 3

Duration 11.2 s, Accuracy Estimate 1.228 (lower is better)

Circle Segment 4

Duration 10.16 s, Accuracy Estimate 1.254 (lower is better)

Circle Segment 5

Duration 9.08 s, Accuracy Estimate 1.316 (lower is better)

Circle Segment 6

Duration 12.4 s, Accuracy Estimate 1.222 (lower is better)

Circle Segment 7

Duration 11.68 s, Accuracy Estimate 1.274 (lower is better)

Circle Segment 8

Duration 9.04 s, Accuracy Estimate 1.27 (lower is better)

Circle Segment 9

Duration 9.04 s, Accuracy Estimate 1.385 (lower is better)

Circle Segment 10

Duration 9.16 s, Accuracy Estimate 1.804 (lower is better)

Spiral

numSpirals 10
timePerSpiralMean 28.888
timePerSpiralCoV 0.0785828
timePerSpiralSlope -0.00115808
meanError 1.47609
tremorFreq 5.95703
tremorRelPower 29.9255
tremorGyroAmpMean 0.0123338
tremorGyroAmpSlope 0.000748052
tremorGyroAmpCoV 0.359472
tremorCoordAmpMean 0.0363436
tremorCoordAmpSlope 0.000632365
tremorCoordAmpCoV 0.26372
tremorAccAmpMean 0.0244702
tremorAccAmpSlope 0.00153544
tremorAccAmpCoV 0.431745
tremorPcRelVar 0.611056
tremorPcX -0.19584
tremorPcY 0.980636

Spiral Segment 1

Duration 27.36 s, Accuracy Estimate 1.637 (lower is better)

Spiral Segment 2

Duration 27.8 s, Accuracy Estimate 1.375 (lower is better)

Spiral Segment 3

Duration 30.0 s, Accuracy Estimate 1.405 (lower is better)

Spiral Segment 4

Duration 31.4 s, Accuracy Estimate 1.617 (lower is better)

Spiral Segment 5

Duration 27.52 s, Accuracy Estimate 1.595 (lower is better)

Spiral Segment 6

Duration 28.32 s, Accuracy Estimate 1.354 (lower is better)

Spiral Segment 7

Duration 33.84 s, Accuracy Estimate 1.456 (lower is better)

Spiral Segment 8

Duration 27.16 s, Accuracy Estimate 1.47 (lower is better)

Spiral Segment 9

Duration 28.96 s, Accuracy Estimate 1.363 (lower is better)

Spiral Segment 10

Duration 26.52 s, Accuracy Estimate 1.488 (lower is better)

Elel

eDurationMean 0.558448
eDurationStd 0.126267
eDurationStdnorm 0.226104
eDurationMedian 0.535019
eDurationQuartdelta 0.155005
eDurationQuartdeltanorm 0.28972
eDurationKurt 3.66963
eDurationTrenddiff 0.0550019
eDurationTrendratio 1.11111
eWidthMean 6.65558
eWidthStd 1.72004
eWidthStdnorm 0.258436
eWidthMedian 6.786
eWidthQuartdelta 3.11173
eWidthQuartdeltanorm 0.458552
eWidthKurt 1.71272
eWidthTrenddiff -2.925
eWidthTrendratio 0.642857
eHeightMean 17.0734
eHeightStd 2.68004
eHeightStdnorm 0.156971
eHeightMedian 17.433
eHeightQuartdelta 3.61107
eHeightQuartdeltanorm 0.20714
eHeightKurt 2.76964
eHeightTrenddiff -0.351
eHeightTrendratio 0.979866
eAspectMean 0.392203
eAspectStd 0.0912037
eAspectStdnorm 0.232542
eAspectMedian 0.381753
eAspectQuartdelta 0.16
eAspectQuartdeltanorm 0.41912
eAspectKurt 1.91916
eAspectTrenddiff -0.158835
eAspectTrendratio 0.675712
eSlantMean 0.168259
eSlantStd 0.0962484
eSlantStdnorm 0.572024
eSlantMedian 0.159739
eSlantQuartdelta 0.130466
eSlantQuartdeltanorm 0.816746
eSlantKurt 2.57771
eSlantTrenddiff -0.0964957
eRtopMean 0.878481
eRtopStd 0.068068
eRtopStdnorm 0.0774837
eRtopMedian 0.884297
eRtopQuartdelta 0.0887049
eRtopQuartdeltanorm 0.100311
eRtopKurt 3.00212
eRtopTrenddiff -0.0793291
eRbotMean 0.475327
eRbotStd 0.160265
eRbotStdnorm 0.337168
eRbotMedian 0.461586
eRbotQuartdelta 0.25906
eRbotQuartdeltanorm 0.561239
eRbotKurt 2.35975
eRbotTrenddiff 0.142597
eRrightMean 0.939347
eRrightStd 0.0404536
eRrightStdnorm 0.0430656
eRrightMedian 0.945769
eRrightQuartdelta 0.0523512
eRrightQuartdeltanorm 0.0553531
eRrightKurt 3.93273
eRrightTrenddiff -0.0368588
eRleftMean 0.274736
eRleftStd 0.0901642
eRleftStdnorm 0.328185
eRleftMedian 0.266075
eRleftQuartdelta 0.137436
eRleftQuartdeltanorm 0.516532
eRleftKurt 2.2179
eRleftTrenddiff 0.058914
lDurationMean 0.820323
lDurationStd 0.463931
lDurationStdnorm 0.565546
lDurationMedian 0.735026
lDurationQuartdelta 0.270009
lDurationQuartdeltanorm 0.367347
lDurationKurt 24.9296
lDurationTrenddiff -0.0500018
lDurationTrendratio 0.936306
lWidthMean 12.7809
lWidthStd 19.85
lWidthStdnorm 1.5531
lWidthMedian 9.01844
lWidthQuartdelta 3.393
lWidthQuartdeltanorm 0.376229
lWidthKurt 31.1861
lWidthTrenddiff -2.34
lWidthTrendratio 0.787234
lHeightMean 31.1774
lHeightStd 3.22135
lHeightStdnorm 0.103323
lHeightMedian 31.3872
lHeightQuartdelta 4.18917
lHeightQuartdeltanorm 0.133467
lHeightKurt 2.83706
lHeightTrenddiff 2.06013
lHeightTrendratio 1.06762
lAspectMean 0.436121
lAspectStd 0.781044
lAspectStdnorm 1.79089
lAspectMedian 0.295846
lAspectQuartdelta 0.130596
lAspectQuartdeltanorm 0.441431
lAspectKurt 31.3255
lAspectTrenddiff -0.108547
lAspectTrendratio 0.702476
lSlantMean 0.280386
lSlantStd 0.809732
lSlantStdnorm 2.88792
lSlantMedian 0.141793
lSlantQuartdelta 0.125251
lSlantQuartdeltanorm 0.88334
lSlantKurt 31.046
lSlantTrenddiff -0.0967037
lRtopMean 0.889524
lRtopStd 0.0743331
lRtopStdnorm 0.0835651
lRtopMedian 0.908121
lRtopQuartdelta 0.0962519
lRtopQuartdeltanorm 0.10599
lRtopKurt 2.9986
lRtopTrenddiff -0.0155765
lRbotMean 0.448851
lRbotStd 0.247361
lRbotStdnorm 0.551098
lRbotMedian 0.401858
lRbotQuartdelta 0.254685
lRbotQuartdeltanorm 0.633768
lRbotKurt 4.40883
lRbotTrenddiff 0.210602
lRrightMean 0.936048
lRrightStd 0.0492092
lRrightStdnorm 0.0525712
lRrightMedian 0.953858
lRrightQuartdelta 0.0462983
lRrightQuartdeltanorm 0.0485379
lRrightKurt 5.19013
lRrightTrenddiff 0.000137125
lRleftMean 0.247385
lRleftStd 0.114891
lRleftStdnorm 0.464422
lRleftMedian 0.249359
lRleftQuartdelta 0.136571
lRleftQuartdeltanorm 0.547689
lRleftKurt 4.05611
lRleftTrenddiff 0.11582

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

FITTS Short Modified

meanTouchScore 0.97219
sumTouchScores 21.3882
meanMovementTime 0.748333
numTouches 22
undershootPercentage 0
overshootPercentage 9.09091

fitts_short data not in signals file.

FITTS Long Modified

meanTouchScore 0.840997
sumTouchScores 11.774
meanMovementTime 1.01308
numTouches 14
undershootPercentage 0
overshootPercentage 35.7143

fitts_long data not in signals file.

ZigZag

numZigzags 5
timePerZigzagMean 28.312
timePerZigzagCoV 0.196529
timePerZigzagSlope -0.0343317
meanError 2.43319
tremorFreq 6.34766
tremorRelPower 20.5831
tremorGyroAmpMean 0.0174985
tremorGyroAmpSlope -0.00129018
tremorGyroAmpCoV 0.367079
tremorCoordAmpMean 0.0482783
tremorCoordAmpSlope -0.00213884
tremorCoordAmpCoV 0.614653
tremorAccAmpMean 0.0504674
tremorAccAmpSlope -0.000108344
tremorAccAmpCoV 0.141037
tremorPcRelVar 0.73399
tremorPcX 0.153545
tremorPcY 0.988142

ZigZag Segment 1

Duration 36.84 s, Accuracy Estimate 2.301 (lower is better)

ZigZag Segment 2

Duration 24.04 s, Accuracy Estimate 2.522 (lower is better)

ZigZag Segment 3

Duration 23.16 s, Accuracy Estimate 2.514 (lower is better)

ZigZag Segment 4

Duration 27.04 s, Accuracy Estimate 2.475 (lower is better)

ZigZag Segment 5

Duration 30.48 s, Accuracy Estimate 2.354 (lower is better)

ZigZag Offset

numZigzags 6
timePerZigzagMean 24.06
timePerZigzagCoV 0.150167
timePerZigzagSlope -0.0461228
zigzagHeightMean 83.0546
zigzagHeightCoV 0.0355653
zigzagHeightSlope -0.00148589
meanError 0.0522867
tremorFreq 5.66406
tremorRelPower 38.4027
tremorGyroAmpMean 0.0256442
tremorGyroAmpSlope 0.00227402
tremorGyroAmpCoV 0.332228
tremorCoordAmpMean 0.0580306
tremorCoordAmpSlope 0.00229065
tremorCoordAmpCoV 0.283676
tremorAccAmpMean 0.0891668
tremorAccAmpSlope 0.000101774
tremorAccAmpCoV 0.115188
tremorPcRelVar 0.833428
tremorPcX 0.186717
tremorPcY 0.982414

ZigZag Offset Segment 1

Duration 22.64 s, Accuracy Estimate 0.049 (lower is better)

ZigZag Offset Segment 2

Duration 27.88 s, Accuracy Estimate 0.045 (lower is better)

ZigZag Offset Segment 3

Duration 27.36 s, Accuracy Estimate 0.077 (lower is better)

ZigZag Offset Segment 4

Duration 25.08 s, Accuracy Estimate 0.031 (lower is better)

ZigZag Offset Segment 5

Duration 23.36 s, Accuracy Estimate 0.033 (lower is better)

ZigZag Offset Segment 6

Duration 18.04 s, Accuracy Estimate 0.079 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.73}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.68}
BM_May22 {‘BM_May22_class’: ‘PD’, ‘BM_May22_score’: 0.99999985175081}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.8420561762700083}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘PD’, ‘BM_PD_Sep22_score’: 0.7656774390303933}